Urticaria and Angioedema: How to Treat Acute and Chronic Hives Effectively

What You’re Really Dealing With

It starts with a rash-red, raised, itchy welts that come and go like clockwork. Maybe your lips swell up overnight. Or your tongue feels thick, your throat tightens. You reach for the antihistamine you used last time, but this time it doesn’t help. That’s when you realize: this isn’t just a simple allergic reaction. You’re dealing with urticaria (hives) and possibly angioedema-two conditions that look similar but demand completely different approaches.

One in five people will get hives at least once in their life. About 1% will develop chronic hives that last longer than six weeks. And for 10 to 20% of those with hives, swelling beneath the skin-angioedema-shows up too. The scary part? Most people don’t know the difference between histamine-driven swelling and bradykinin-driven swelling. And that mistake can be dangerous.

Acute vs. Chronic: The Two Faces of Hives

Acute urticaria lasts less than six weeks. It often has a clear trigger: a new medication, shellfish, a bee sting, or even a viral infection. If you took a new antibiotic or switched to a different blood pressure pill, that’s likely the culprit. The good news? Most acute cases resolve on their own within 24 to 48 hours with simple treatment.

Chronic urticaria is different. It’s not about what you ate or touched. It’s your own immune system misfiring. Around 75 to 80% of chronic cases are called chronic spontaneous urticaria-meaning no obvious trigger exists. You wake up with hives. You go to bed with hives. It comes and goes for months, sometimes years. The itch is relentless. Sleep suffers. Anxiety builds. And the standard advice-“take an antihistamine”-often doesn’t cut it.

Angioedema: When Swelling Goes Deeper

Angioedema isn’t just bigger hives. It’s swelling in deeper layers-lips, eyelids, tongue, throat, even the gut. The key question: is it histamine-driven or bradykinin-driven?

If your swelling comes with itching, redness, and hives, it’s histamine-driven. That’s the kind antihistamines help. But if your lips swell without itching, and you’re on an ACE inhibitor like lisinopril or enalapril? That’s bradykinin-mediated. Antihistamines won’t touch it. Epinephrine won’t help. Steroids? Useless. And if your tongue is swelling and you’re drooling or struggling to breathe? That’s an emergency. You need airway management, not more pills.

ACE inhibitors cause about 20% of all angioedema cases. If you’re on one and you develop swelling, stop it immediately. Symptoms usually fade within 3 to 4 months after stopping. But don’t just switch to another blood pressure pill. ARBs like losartan are safer-but still carry a 10% risk of angioedema. Talk to your doctor before making any changes.

First-Line Treatment: Antihistamines Done Right

For histamine-driven hives and angioedema, non-sedating antihistamines are the foundation. But most people take them wrong.

Standard doses-cetirizine 10mg, loratadine 10mg, fexofenadine 180mg-are often not enough. The British Society for Allergy and Clinical Immunology recommends increasing the dose up to four times the normal amount if symptoms persist. That means:

• Cetirizine: 20mg to 40mg daily
• Fexofenadine: 360mg to 540mg daily (split into morning and evening doses)
• Loratadine: 20mg daily

This isn’t off-label in the sense of being unsafe-it’s evidence-based. Studies show response rates jump from 50% at standard doses to 70-80% at higher doses. Many patients don’t know they can take more. Their doctor didn’t tell them. So they stop after a week, convinced it’s not working.

Don’t take these on an as-needed basis. Take them daily, even when you’re symptom-free, for at least two weeks. Hives are like a fire-you need to keep the water on until the embers cool.

When Antihistamines Fail: What Comes Next

If doubling or quadrupling your antihistamine doesn’t help, it’s time to think bigger. For chronic spontaneous urticaria, the next step is omalizumab-a monthly injection that blocks IgE, the antibody that triggers mast cells.

Omalizumab works in 60 to 70% of people who don’t respond to high-dose antihistamines. It’s not cheap-around £1,200 a month in the UK-but it’s life-changing. You stop worrying about where the next hive will appear. You sleep again. You go out without hiding your skin.

But you can’t get it from your GP. You need a referral to an allergy or immunology specialist. That’s the rule in most countries, including Australia. Don’t wait for your doctor to bring it up. If you’ve been struggling for months, ask: “Could I be a candidate for omalizumab?”

The Steroid Trap

Doctors often reach for prednisone when hives won’t quit. “Take this for five days,” they say. It works-fast. The hives vanish. You feel like a new person.

But here’s the truth: steroids don’t fix the cause. They just suppress the immune system temporarily. And if you use them longer than 10 days, the side effects pile up: weight gain, mood swings, high blood sugar, bone loss, insomnia. Worse-they do nothing for bradykinin-mediated angioedema. That’s a critical point. If your swelling isn’t itchy, steroids won’t help. They just add risk.

Use steroids only for severe acute cases with throat swelling, and only for 5 to 10 days max. Never for chronic hives. There are better, safer options now.

What to Avoid

Some triggers are obvious. But others slip under the radar.

• NSAIDs: Ibuprofen, naproxen, diclofenac. They worsen hives in 20 to 30% of chronic cases. Switch to paracetamol (acetaminophen) if you need pain relief.
• ACE inhibitors: Lisinopril, ramipril, enalapril. Stop them immediately if angioedema develops. Don’t wait. Don’t hope it’ll pass.
• DPP4 inhibitors: Medications like sitagliptin (“gliptins”) for diabetes. Rare, but linked to angioedema. If you’re on one and develop swelling, tell your doctor.
• Alcohol and stress: Both can worsen symptoms, even if they don’t cause them directly.

Keep a simple journal: What did you eat? What meds did you take? Did you feel stressed? Did the hives appear after exercise, heat, or cold? Patterns emerge over time.

Special Cases: Pregnancy, Breastfeeding, and Kids

If you’re pregnant or breastfeeding, you still have options. Cetirizine and loratadine are considered safe at standard doses. Avoid higher doses unless absolutely necessary and under specialist supervision. Fexofenadine is less studied in pregnancy-stick to the safer ones.

For children, dosing is weight-based. Always check with a pediatrician. Antihistamines are generally safe for kids over 2, but never give adult doses.

When to Seek Emergency Help

Not every swelling is an emergency. But these signs mean you need to go to the hospital now:

• Difficulty breathing or swallowing
• Stridor (a high-pitched sound when breathing)
• Drooling or inability to swallow saliva
• Tongue or throat swelling
• Feeling like your airway is closing

If you have these symptoms, call emergency services. Don’t wait. Don’t try to drive yourself. Epinephrine auto-injectors (like EpiPen) are only for histamine-driven reactions. They won’t help if your swelling is from an ACE inhibitor. But if you’re unsure-use it anyway. Better safe than sorry.

Long-Term Outlook

Chronic hives are frustrating, but they’re not permanent. Around 65 to 75% of people with chronic spontaneous urticaria go into remission within five years. The itch fades. The swelling stops. You get your life back.

But you have to play the long game. Don’t give up after one bad week. Don’t stop your meds just because you feel better. Work with your doctor. Track your progress. Ask about omalizumab if standard treatment fails. And if you have angioedema without itching-know your type. That changes everything.

Final Thought: You’re Not Alone

Chronic hives and angioedema are invisible illnesses. People don’t see the sleepless nights, the anxiety, the constant checking of your skin. But you’re not alone. Thousands of people are going through this right now. And there’s a clear path forward-once you know the rules.

Stop guessing. Start treating based on evidence. Know your type. Know your triggers. Know your options. And if your doctor doesn’t know the latest guidelines? Bring them. The research is out there. You just need to ask for it.