Paroxetine: Uses, Side Effects and Safe Tips
Paroxetine is an SSRI antidepressant commonly prescribed for depression, panic disorder, generalized anxiety, social anxiety, obsessive‑compulsive disorder (OCD), PTSD, and premenstrual dysphoric disorder (PMDD). It boosts serotonin in the brain, which can help mood and anxiety, but it doesn’t work right away. Most people notice changes after 2–6 weeks.
How to use paroxetine safely
Doctors usually start low and adjust. Typical starting doses are 10–20 mg daily for immediate‑release tablets; some people move to 20–50 mg depending on response and tolerance. There’s also a controlled‑release form that may cause fewer side effects. Take it at the same time every day—morning or night—based on whether it makes you sleepy or wired.
Common tips: take with food if you get nausea, don’t crush or chew extended‑release pills, and keep a simple list of all medicines and supplements you use. Paroxetine interacts with several drugs: avoid mixing with MAO inhibitors (you’ll need a washout period), be cautious with other antidepressants or tramadol (risk of serotonin syndrome), and watch bleeding risk if you’re on blood thinners or NSAIDs.
Do not stop paroxetine suddenly. Stopping abruptly often causes withdrawal symptoms like dizziness, flu‑like feelings, or sensory disturbances. If you and your doctor decide to stop, plan a gradual taper over weeks to months depending on dose and how long you’ve been taking it.
Side effects, withdrawal and red flags
Expect some mild side effects at first: nausea, tiredness or drowsiness, dry mouth, constipation, sweating, or headache. Sexual side effects (reduced libido, delayed orgasm) and weight changes are common for some people. These might improve with time, dose changes, or switching medications—talk to your prescriber if they’re bothersome.
Be aware of serious but less common problems. If you notice new or worsening suicidal thoughts—especially under age 25—contact your doctor right away. Watch for signs of serotonin syndrome (high fever, fast heartbeat, severe agitation, tremor) and seek emergency care if that happens. Also call your provider for severe allergic reactions, easy bruising or bleeding, fainting, or chest pain.
Pregnancy and breastfeeding need discussion with your doctor. Paroxetine has risks in pregnancy and may not be the best choice for everyone. Your clinician can weigh benefits and alternatives.
Practical checklist: keep a single medication list, avoid alcohol if paroxetine causes drowsiness, report mood changes or suicidal thoughts, never mix with MAOIs, and plan gradual tapering if stopping. Questions? Talk with your prescriber or pharmacist so you can use paroxetine safely and get the most benefit from it.
